Recurrent Prostate Cancer Diagnostics with 18F-PSMA-1007 PET/CT: A Systematic Review of the Current State

Funding Information: This research was funded by Latvian Council of Science, grant number: lzp-2019/1-0056 “Impact of Targeted Molecular Imaging with 18F-PSMA-1007 and 68Ga-PSMA-11 PET/CT in Multimodal Evaluation of Recurrent Prostate Cancer”. This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 101008571 (PRISMAP). This document reflects only the view of the author(s). The funding agenc(y/ies) is/are not responsible for any use that may be made of the information it contains. Publisher Copyright: © 2022 by the authors.BACKGROUND: Early diagnosis of recurrent prostate cancer is a cornerstone for further adequate therapy planning. Therefore, clinical practice and research still focuses on diagnostic tools that can detect prostate cancer in early recurrence when it is undetectable in conventional diagnostic imaging. 18F-PSMA-1007 PET/CT is a novel method to evaluate patients with biochemical recurrent PCa. The aim of this review was to evaluate the role of 18F-PSMA-1007 PET/CT in prostate cancer local recurrence, lymph node metastases and bone metastases detection. METHODS: Original studies, reviews and five meta-analyses were included in this article. A total of 70 studies were retrieved, 31 were included in the study. RESULTS: All patients described in the studies underwent 18F-PSMA-1007 PET/CT. The administered 18F-PSMA-1007 individual dose ranged from 159 ± 31 MBq to 363.93 ± 69.40 MBq. Results showed that 18F-PSMA-1007 PET/CT demonstrates a good detection rate in recurrent prostate cancer. CONCLUSIONS: 18F-PSMA-1007 PET/CT appears to achieve reliable performance in detecting recurrent prostate cancer. The high detection rate of 18F-PSMA-1007 PET/CT in recurrent prostate cancer was confirmed, especially in local recurrence and small lymph nodes with non-specific characteristics on conventional diagnostic imaging methods. However, several authors emphasize some limitations for this tracer-for example, non-specific uptake in bone lesions that can mimic bone metastases.publishersversionPeer reviewe

Diagnostic scope of 18 F-PSMA-1007 PET/CT : comparison with multiparametric MRI and bone scintigraphy for the assessment of early prostate cancer recurrence

publishersversionPeer reviewe

Radiological examination of the hip joint after operation

Gūžas locītavas totāla endoprotezēšana ir viena no visaktuālākajām operācijām traumatoloģijā un ortopēdijā, kura, šodien, nav iedomājama bez preoperatīvas radioloģiskās operāciju plānošanas un postoperatīvas radioloģiskas novērtēšanas. Šī reparatīvā metode dod pacientiem iespēju atgūt locītavas funkcionālās spējas, pārvietoties bez sāpēm un uzlabo dzīves kvalitāti. Savukārt dislokācija pēc totālas gūžas locītavas endoprotezēšanas operācijas ir viena no būtiskajām un aktuālajām problēmām, kura skar gan pacientu, gan ārstu, gan veselības sistēmu kopumā. Pētījuma mērķis un zinātniskais jautājums ir - noteikt vai acetabulārie komponenti, kurus implantē VSIA „Traumatoloģijas un ortopēdijas slimnīcā”, ir implantēti drošības zonā gan pēc Levinneka datiem, gan pēc Vidmera datiem un atrast faktorus, kuri palielina dislokācijas risku. Pētījumā tika noteikts, ka 83,6% acetabulārais komponents tika implantēts Levinneka noteiktajā drošības diapazonā, un 27,77% Vidmera noteiktajā drošības diapazonā. Pētījumā tika noteikta statistiski ticama atšķirība acetabulāra komponenta pozicionēšanās laikā, to veicot ārstam ar lielāko pieredzi un mazāko pieredzi. Taču netika atrasta statistiski ticama atšķirība attiecībā pret dislokācijas biežumu, implantējot acetabulāro komponentu Levinneka un Vidmera drošības zonās.Total hip replacement arthroplasty is one of the timeliest operations in traumatology and orthopedics, which today is unthinkable without preoperative radiological operations planning and post-operative radiological evaluation. This reparative method gives patients the opportunity to regain functional joints ability to move without pain and improves quality of life. In turn, dislocation after total hip replacement surgery is one of the most essential and current problems which affect both patients and physicians, and the health system as a whole. Aim of the research and scientific issue - to determine whether acetabular components implanted by VSIA "Traumatology and Orthopedics Hospital", are implanted in the safety zone by Lewinnek data as well as by Widmer data and find the factors that increase the risk of dislocation. In study it was determined that in 83.6% acetabular component was implanted in Lewinnek prescribed safety range, and in 27.77% in Widmera prescribed safety range. The study determined statistically significant difference in time of acetabular components positioning, by a doctor with the most experience and the smallest experience. Statistically significant difference was not found with respect to the deployment frequency of implantation of acetabular component in Lewinneka and Widmera safety zones